Definition:
Lambert-Eaton Myasthenic Syndrome is a rare autoimmune disorder that involves the neuromuscular junction. It has a great similarity with Myasthenia Gravis, but there are also obvious distinctions with the symptoms and pathogenetic features between the two medical conditions.
The disease is common in middle aged and older people; however, this is not a guarantee that young people will have no chances of suffering the disease.
Diagnosis:
Clinical and laboratory findings are methods used to establish diagnosis of this syndrome.
Treatment:
Treatment of Lambert-Eaton Myasthenic Syndrome with corticosteroids, azathioprine, and 3, 4-diaminopyridine has not yet gained success with regards to completely curing the condition.
Plasma exchange or intravenous immunoglobulin can also be tried in the hope to aid treatment of this medical condition.
Symptoms and Signs:
Autonomic symptoms of Lambert-Eaton Myasthenic Syndrome includes dry mouth, impotence or reduced or loss of reflexes. Clinical findings may reveal progressive weakness without the involvement of respiratory and face muscles. The most affected parts are the proximal parts of the legs and arms. Patients may also suffer from muscular pain and tenderness.
Other associated symptoms include:
* Sensory neuropathy
* Difficulty in urinating
* Constipation
Causes:
Lambert-Eaton Myasthenic Syndrome is caused by antibodies that are directed against the antigens of the junction between nerve and muscle.
:
lamberteatonmyasthenicsyndrome
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