Definition:
Langerhans cell histiocytosis is a medical condition characterized with the increased production of Langerhans cell. Langerhans cell are abnormal cells originating from the bone marrow and have the capability to drift from the skin to the lymph nodes.
Langerhans cell histiocytosis was formerly referred to as histiocytosis X. The Histiocyte society renamed the disease in 1985.
Diagnosis:
Histological portion of Langerhans cell histiocytosis is diagnosed by means of tissue biopsy. Other diagnostic methods can also be vital like routine blood tests, Radiology, Magnetic Resonance Imaging (MRI), endocrine function evaluation and bone marrow biopsy.
Treatment:
Treatment is usually based depending on the coverage of the disorder. Excision or limited radiation may serve as an agreeable option in treating single bone lesion. Skin lesions are typically treated with local steroid creams. Chemotherapy is highly suggested for systemic diseases. Deficient endocrine function may be relieved with lifetime and permanent supplements.
Symptoms and Signs:
Langerhans cell histiocytosis exhibits the following signs and symptoms:
* Inflammatory responses like pain, fever, localized swelling
* Reduced awareness of the environment and reduced alertness
* Unexplainable weight loss
* Localized bone degeneration
* Skin rash that appear as scaly erythematous
* Excessive drinking of water due to periods of excessive thirst
* Increased urination
* Loss of appetite
* Anemia and blood cell deficiencies
* Inadequate or interrupted physical growth
* Cough
* Difficulty in breathing
* Swollen lymph glands
* Fatigue
Causes:
Langerhans cell histiocytosis is caused by the proliferation of Langerhans cells.
:
langerhanscellhistiocytosis
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