Definition:
Globoid cell leukodystrophy, or Krabbe disease, is a rare, fatal degenerative disease that destroys the myelin content of the nervous system.
Diagnosis:
Globoid cell leukodystrophy can be diagnosed through nerve demyelination, destruction of brain cells and a characteristic grouping of multinucleated globoid cells.
Treatment:
There is no exact cure for the disease, but bone marrow transplant has shown potential effects that could lead to recovery, although this has only been tried on mild cases.
Symptoms and Signs:
Persons affected with Globoid cell leukodystrophy begin to experience symptoms at age three. They start to suffer from consistent irritabitlity, limb stiffness, eating difficulties, vomiting, as well as slow mental and motor development. Others meanwhile undergo lethargy, spasticity, optic atrophy, deafness and eventual paralysis.
Causes:
Globoid cell leukodystrophy is an autosomal recessive genetic disorder.
:
leukodystrophygloboidcell
The information on this site is for research purposes only and can not substitute for the advice of a medical professional. Ailments.com is not run by doctors and does not engage in the practice of medicine. Our site is not a medical authority, it is just a research tool for you to use in preparation for consulting with a doctor. We can not guarantee our information is accurate or up to date. Even if a statement made about a medical condition is accurate, it may not apply to you or your symptoms, so you should always consult a doctor. Nothing on our site should be construed as an attempt to offer or render a medical opinion or otherwise engage in the practice of medicine.
