Definition:
Lutz-Lewandowsky epidermodysplasia verruciformis, more commonly known simply as epidermodysplasia verruciformis, is a rare lifelong skin condition wherein scaly macules and papules abnormally form on the hands and feet. This disease initially develops in childhood and last throughout adulthood.
Diagnosis:
A biopsy is recommended to detect premalignant and malignant lesions at the onset. Telltale lesions may appear in the epidermis. Classic histoligic manifestations may also form the basis for diagnosis.
Treatment:
Currently, there is no known cure for epidermodysplasia verruciformis. High doses of vitamin A may, however, provide some symptomatic relief.
Symptoms and Signs:
Flat, wart-like lesions appear on the skin, with scaly, hyperpigmentated or hypopigmentated patches. Flat macules and reddish scaly plaques are common signs of this condition. Papules appearing on knees, elbows, and trunk may eventually combine to form bigger plaques.
The wart-like lesions are often visible on areas of the skin that are frequently exposed to the sun. Main localization points are the feet, hands, and face. Pigmentation usually affects the trunk of the body, the neck, and proximal extremities. Lesions may invade palms and soles, in the axillae, as well as on the external genitalia.
Causes:
The human papilloma virus is considered as the cause of epidermodysplasia verruciformis. Strains 5 and 8 of the said virus are believed to be the main contributing factors.
There is also evidence of genetic disposition to this skin disease, a factor that may explain why this condition is extremely rare. Papilloma viruses are found in only 15-20% of normal skin with no heightened incidence of cancer.
:
lutzlewandowskyepidermodysplasiaverruciformis
The information on this site is for research purposes only and can not substitute for the advice of a medical professional. Ailments.com is not run by doctors and does not engage in the practice of medicine. Our site is not a medical authority, it is just a research tool for you to use in preparation for consulting with a doctor. We can not guarantee our information is accurate or up to date. Even if a statement made about a medical condition is accurate, it may not apply to you or your symptoms, so you should always consult a doctor. Nothing on our site should be construed as an attempt to offer or render a medical opinion or otherwise engage in the practice of medicine.
