Definition:
Marchiafava-Bignami disease is also known as Marchiafava's disease and Marchiafava's syndrome. It is a progressive neurological disorder oftentimes associated with alcohol abuse and/or nutritional disorder.
Symptoms and Signs:
Marchiafava-Bignami disease presents some or all of the following signs and symptoms:
* Remarkable change in a person's mental aspect.
* Lack of absence of feeling and emotion.
* Involuntary contractions of voluntary muscles (convulsions)
* Involuntary trembling (tremors)
* Speaking difficulty
* Sphincter alteration
* Mental confusion and impaired thought (dementia)
* Demyelination of corpus callosum.
* Stupor
* Sensation of increased anxiety and anticipation.
* Coma
* Fits
Causes:
Marchiafava-Bignami disease is traditionally associated with chronic alcohol abusers who are habitual and prolonged drinkers of cheap Italian red wine. Though there are also occurrences in non-alcoholics.
Marchiafava-Bignami disease is due to demyelination of the corpus callosum and laminar necrosis in the frontal and temporal lobes of the brain.
:
marchiafavabignamidisease
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