Marchiafava-Bignami disease is also known as Marchiafava’s disease and Marchiafava’s syndrome. It is a progressive neurological disorder oftentimes associated with alcohol abuse and/or nutritional disorder.

Marchiafava-Bignami disease presents some or all of the following signs and symptoms: * Remarkable change in a person’s mental aspect. * Lack of absence of feeling and emotion. * Involuntary contractions of voluntary muscles (convulsions) * Involuntary trembling (tremors) * Speaking difficulty * Sphincter alteration * Mental confusion and impaired thought (dementia) * Demyelination of corpus callosum. * Stupor * Sensation of increased anxiety and anticipation. * Coma * Fits

Marchiafava-Bignami disease is traditionally associated with chronic alcohol abusers who are habitual and prolonged drinkers of cheap Italian red wine. Though there are also occurrences in non-alcoholics. Marchiafava-Bignami disease is due to demyelination of the corpus callosum and laminar necrosis in the frontal and temporal lobes of the brain.