Definition:
Mastocytosis is a disorder that results when too many mast cells, called mastocytes, and CD34+ mast cell precursors exist in the body. It has many types and may be experienced by children and adults.
Diagnosis:
In the case of urticaria pigmentosa or cutaneous mastocytosis, doctors examine a skin sample with distinct dark-brown and fixed lesions to confirm the existence of the disorder. In a systemic mastocytosis, doctors examine a sample from an organ like the bone marrow to examine whether there is an increase in mast cells. The disorder may also be determined through presence of high levels of certain mast-cell chemicals and proteins in the blood or urine.
Treatment:
Currently, mastocytosis has no cure but some medicines exist only treat the symptoms. Such medicines include Antihistamines, Leukotriene, or mast cell stabilizers. However, only Cromolyn Sodium Oral Solution is approved by the U.S. FDA for treating mastocytosis. Clinical trials that test stem cell transplants are also forms of treatment. Some patients also join support groups for emotional therapy.
Symptoms and Signs:
In rare cases, the body's immune system is affected showing symptoms characteristic to allergies like itching, abdominal cramps, and anaphylaxis. The patient may also experience skin lesions, bone/muscle pain, nausea and vomiting or, very low blood pressure and faintness
Causes:
Mastocytosis results when too many mastocytes and CD34+ mast cell precursors exists, which the body cannot handle.
The information on this site is for research purposes only and can not substitute for the advice of a medical professional. Ailments.com is not run by doctors and does not engage in the practice of medicine. Our site is not a medical authority, it is just a research tool for you to use in preparation for consulting with a doctor. We can not guarantee our information is accurate or up to date. Even if a statement made about a medical condition is accurate, it may not apply to you or your symptoms, so you should always consult a doctor. Nothing on our site should be construed as an attempt to offer or render a medical opinion or otherwise engage in the practice of medicine.
