Definition:
Mastocytosis is a group of unusual disorder of both children and adults caused by the presence of too many mast
cells (mastocytes) and CD34+ mast cell precursors in a person's body.
Diagnosis:
Doctors can diagnose urticaria pigmentosa (cutaneous mastocytosis, see below) by seeing the characteristic lesions
that are dark-brown and fixed. A tiny skin sample (biopsy) may help confirm the diagnosis.
Treatment:
There is currently no cure for mastocytosis. However, there are a number of medicines to help treat the symptoms
of mastocytosis: Antihistamines block receptors targeted by histamine released from mast cells. Both H1 and H2
blockers can be helpful. Leukotriene antagonists block receptors targeted by leukotrienes removed from mast cells.
A mast cell stabilizer helps prevent mast cells from releasing their chemical contents. Cromolyn Sodium Oral
Solution (Gastrocrom / Cromoglicate) is the only one medicine specifically approved by the U.S.FDA for the
treatment of mastocytosis.
Symptoms and Signs:
In some rare cases chemicals released by mast cells cause changes in the immune system leading to typical allergy
symptoms such as: Itching, Abdominal cramping, Anaphylaxis (shock from allergic or immune causes), When too many
mast cells exist in a person's body, the additional chemicals can cause: Skin lesions, Abdominal discomfort,
Episodes of very low blood pressure (including shock) and faintness, Bone or muscle pain, Nausea and vomiting
Causes:
Causes of underlying conditions the possible cause mastocytosis includes: Cancer and Blood disorder.
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