Definition:
Ochronosis is a metabolic disorder causing excessive homogentisic acid in the body. The face, skeletal system, cardiovascular system, respiratory system, urinary system and skin show adverse pigmentation, calcification, and inflammation.
Symptoms and Signs:
The patient has dark urine, pigmented skin and arthritis.
Causes:
The disorder is a result of incomplete metabolism of homogentisic acid, tyrosine and phenylalanine.
