Definition:
Paroxysmal cold hemoglobinuria is also termed as Donath-Landsteiner syndrome. This is a disease usually affecting humans and is characterized by abrupt presence of the hemoglobinuria in urine especially after being exposed to very cold temperatures.
Diagnosis:
Diagnosis can be done through urine analysis in the laboratory to check for presence of hemoglobin in the urine sample taken from the patient. Differential diagnosis is then done to know the organism causing the illness.
Treatment:
Treatments for Paroxysmal cold hemoglobinuria vary depending on the causing agent. Antibiotics have been found effective if caused by a bacterial organism. In some cases, it doesn't need immediate treament as it will usually go away after the causing agent has been treated. It also usually don't last long.
Symptoms and Signs:
Patients with this disease often will manifest hemoglobinuria in the urine and can suffer mild to severe anemia.
Causes:
Infections of a microorganism that triggers formation of the body's antibodies that reacts with red blood cell membrane are seen as a cause of the disease Paroxysmal cold hemoglobinuria. Viral organisms include measles,influenza, chickenpox, cytomegalovirus, mumps, adenovirus, and Epstein-Barr virus. Syphilis, Mycoplasma pneumoniae, and Haemophilus influenzae are some bacterial organisms causing Paroxysmal cold hemoglobinuria. It can be also that the disease is the body's reaction some vaccinations.
:
paroxysmalcoldhemoglobinuria
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