Definition:
Reynolds syndrome is a rare disease, autoimmune in origin, characterized by scleroderma (i.e. hardened skin) and cirrhosis of the liver. This syndrome is closely associated with the combination of primary biliary cirrhosis and progressive systemic sclerosis. In some cases, Reynolds syndrome has been associated with hemolytic anemia and Sjögren's syndrome.
Reynolds syndrome is named after Telfer B. Renolds, an American physician who first described it.
Clinical presentations of Reynolds syndrome include elevated levels of alkaline phosphatase in the blood, jaundice, pruritus, and telangietasias. At the onset of Reynolds syndrome, Reynaud's phenomenon may occur as an early symptom.
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