Definition:
Richter syndrome is an extremely rare disease characterized by the transformation of chronic lymphocytic leukemia (CLL) into a rapidly progressive form of lymphoma.
Also known as Richter transformation, this disorder is a type of high grade non Hodgkin's lymphoma affecting patients with chronic lymphocytic leukemia. To date, only 1 in 20 documented cases of CLL leads to Richter syndrome.
Diagnosis:
To diagnose Richter syndrome, a lymph node biopsy followed by substantial blood tests may be done. Other possible diagnostic steps include a bone marrow biopsy and a CT scan.
Treatment:
Standard treatment for chronic lymphocytic leukemia (CLL) will continue even if the affected patients have developed Richter syndrome. Treatment is usually a combination of chemotherapy, radiation therapy, monoclonal antibodies and potentially stem cell implantation.
Symptoms and Signs:
Richter syndrome commonly presents with weight loss, muscle mass loss, fever, and other related health problems.
It is important to note that Richter syndrome is a fast-growing cancer, and affected patients can become quite suddenly ill.
Causes:
Currently, the specific cause of Richter syndrome remains unknown. However, some researches suspect the Epstein Barr virus as the primary trigger. In addition, some theories point to a link between the disease and genetics. It has been proposed that some genes predispose certain individuals to Richter syndrome.
The information on this site is for research purposes only and can not substitute for the advice of a medical professional. Ailments.com is not run by doctors and does not engage in the practice of medicine. Our site is not a medical authority, it is just a research tool for you to use in preparation for consulting with a doctor. We can not guarantee our information is accurate or up to date. Even if a statement made about a medical condition is accurate, it may not apply to you or your symptoms, so you should always consult a doctor. Nothing on our site should be construed as an attempt to offer or render a medical opinion or otherwise engage in the practice of medicine.
