Definition:
Rosai-Dorfman disease pertains to a rare, benign condition characterized by an excess in the production of histiocytes, which build up in the lymph nodes throughout the body. The elevated histiocytes typically accumulate in the lymphadenopathy of the neck. In addition, histiocytes may also build up outside the lymph nodes, particularly in the skin, bone, and upper respiratory tract. Rosai-Dorfman disease presents with a variety of symptoms depending on the site or area of histiocyte accumulation.
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