Definition:
Rotor syndrome is a rare bilirubin disorder inherited via the autosomal recessive trait. Named after Arturo Belleza Rotor, a Filipino internist, Rotor syndrome is a relatively benign disease that starts soon after birth or during early childhood.
Symptoms and Signs:
Rotor syndrome is characterized by elevated levels of bilirubin in the blood. The three most common clinical presentations of rotor syndrome are fluctuating jaundice, epigastric discomfort, and bilirubin in the urine. In some cases, abdominal pain, fever, and liver enlargement may occur.
Jaundice typically appears in childhood as a consequence of defects in biliary excretion. In affected patients, plasma bilirubin is usually conjugated; while liver functions tests appear normal.
Causes:
Rotor syndrome is believed to be a hereditary disorder, autosomal recessive in pattern. It currently has no known origins.
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