Definition:
Schmidt syndrome is an adrenal defect that commonly occurs with another glandular disorder. Schmidt syndrome is also known as “autoimmune polyendocrine syndrome type 2”, a more heterogeneous form of autoimmune polyendocrine syndrome which affects one or more endocrine organs but has also been known to invade other non-endocrine organs.
Schmidt syndrome is a more commonly occurring type of autoimmune polyendocrine syndrome.
Symptoms and Signs:
Schmidt syndrome typically manifests with hypothyroidism, diabetes mellitus type 1, and Addison's disease. Less common manifestations include vitiligo and hypogonadism.
Causes:
Schmidt syndrome has not been linked to a specific gene. However, certain genetic risk factors have been identified; in particular, carriers of a certain HLA genotype seem to be predisposed to the disease.
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