Sharp Syndrome is a rare connective tissue disorder affecting a range of body tissues and organs. It is also referred to as mixed connective tissue disease. Sharp syndrome is a serious auto immune disease, wherein the body's defense system attacks and damage itself.

The overlapping clinical features make it more difficult to diagnose Sharp Syndrome. To ensure proper diagnosis, medical professionals follow original criteria that will help them to diagnose the presence of Sharp Syndrome.

The initial treatment for patients with mild disease is usually with non-steroidal anti-inflammatory medications like Ibuprofen to alleviate the pain and inflammation. Most of the time treatment is aimed at lessening the symptoms present.

Sharp syndrome often present similar symptoms with other disorders like polymyositis, systemic lupus erythematosus, and systemic scleroderma. This is the reason why most of the time Sharp syndrome is often considered as an overlap syndrome. Symptoms of Sharp Syndrome include the following: • Anorexia or loss of appetite • Weight loss • Fever • Paleness • Nausea • Vomiting • Diarrhea • Delirium • Headache • Weakness • Tenosynovitis or inflammation of the tendon sheath marked by severe pain, tenderness, swelling and lump formation • Thickening and hardening of the skin and connective tissue • Discoloration of the fingers, toes and sometimes other extremities (Raynaud's phenomenon) • Muscle inflammation • Joint pain and swelling • Difficulty in swallowing • Pleuritic chest pain • Rash • Baldness

sharpsyndrome