Definition:
Thrombocytosis is the presence of high platelet counts in the blood, and can be either reactive or primary.
Diagnosis:
Laboratory tests might include: liver enzymes, full blood count, renal function and erythrocyte sedimentation rate.
Treatment:
Often, no treatment is needed or necessary for reactive thrombocytosis.
Symptoms and Signs:
High platelet levels do not necessarily signal any clinical concerns, and are picked up on a routine full blood count. However, it is crucial that a full medical history be elicited to ensure that the increased platelet count is not due to a secondary process. Often, it arises in tandem with an inflammatory disease, as the principal stimulants of platelet production (e.g. thrombopoietin) are heightened in these clinical states as part of the acute phase reaction.
Causes:
Primary causes include essential thrombocytosis (a form of myeloproliferative disease) and other myeloproliferative disorders such as chronic myelogenous leukemia, polycythemia vera, myelofibrosis.
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