Definition:
Warkany Syndrome or other wise known as the Trisomy 8 is an aberration in the chromosome that causes severe effects on the fetus. It is often observed in person with chronic myeloid leukaemia which may be a result of instability of the karyotype which is probably due to bcr:abl fusion gene. The Warkany Syndrome is discovered by Joseph Warkany.
Diagnosis:
Diagnosis includes physical as well as laboratory examinations.
Treatment:
There is no known treatment for Warkany Syndrome especially the trisomy 8 mosaicism. Treatment for miscarriage is advised however for those which has complete trisomy 8 inasmuch as it often results to miscarriage.
Symptoms and Signs:
It symptoms includes the retardation especially in psychomotor development, mental retardation, short stature, eye abnormalities and anomalies (Riccardi VM (1977). "Trisomy 8: an international study of 70 patients". Birth Defects Orig. Artic. Ser. 13 (3C): 171-84).
Causes:
It is said to be caused by chromosome aberrations.
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