Definition:
Acquired Willebrand disease otherwise known as the Von Willebrand disease is the a hereditary coagulation abnormality which arises from a quantitative or qualitative deficiency of von Willebrand factor which is a multimeric protein that is usually required for platelet adhesion.
Diagnosis:
Diagnosis includes examination and investigation of blood plasma through measuring the amount of Von Willebrand Factor antigen assay and functionality. Medical laboratories such as complete blood count, activated partial thrompbosplastin time, prothrombin time and thrombin time and platelet function assay are also used to confirm the disease.
Treatment:
There is no regular treatment for the disease hence, person infected usually are at risk for bleeding. Prophylactic treatment is given to patients who will undergo surgery (Mannucci PM. (2004) Treatment of Von Willebrands Disease. N.Engl. J Med, 351:683-94).
Symptoms and Signs:
Symptoms includes varying degrees of bleeding tendency which may be internal. Bruising, nose bleeds and heavy menstrual period and blood loss during childbirth are observed.
Causes:
Acquired Willebrand occurs usually in patients with autoantibodies, to person with aortic valve stenosis.
:
willebranddiseaseacquired
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