Definition:
Autoimmune hepatitis is an abnormal presentation of human leukocyte antigen (HLA) class II on the exterior of hepatocytes it might be because of the hereditary predisposition or severe liver infection that results to a cell-mediated immune response in opposition of the body's liver causing autoimmune hepatitis.
Prevalence:
Autoimmune hepatitis has an occurrence of 1-2 per 100,000 per year and 15-20/100,000 as prevalence. Like with other diseases it affects mostly women the ration is 8:1. Liver enzymes are augmented like bilirubin. Autoimmune can result to cirrhosis when it progresses.
Diagnosis:
Physical exam
Liver function tests
Antinuclear antibodies (ANA) test
Smooth muscle cells (SMA) antibodies
Liver/kidney microsomes (anti-LKM)
Liver biopsy
The diagnosis of autoimmune hepatitis always requires liver biopsy. Scoring system can be used in complicated cases. The best way to achieve the diagnosis is through a combination of laboratory examinations.
Prognosis:
Out of 10 people, 7 people affected by this disease go into reduction with the decreasing of the severity of symptoms within tow years of initial treatment. The part where the disease was reduced will reoccur in about 3 years that is why treatment is needed on and off for years or if not for life.
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