Definition:
Doxorubicin-induced cardiomyopathy is a condition that occurs as a reaction of the Doxorubicin. In this case, it targets the heart.
Diagnosis:
Laboratory and or clinical tests may be administered to diagnose the disorder.
Causes:
It occurs in reaction to Doxurubicin drug, Doxorubicin is a drug, an antineoplastic antibiotic which was produced and developed by Streptomyces peucetius. It binds to DNA and acts as inhibitor of nucleic acid synthesis. It is also used as hydrochloride salt or as a liposome-encased preparation of the others salts like hydrochloride. This is a 14-hydroxylated version of a daunorubicin, which is more abundantly and naturaly found product because it is made by different types of wild strains of streptomyces. However, there is only one known species which is not wild. It is called streptomyces peucetius subspecies cesius ATCC 27952. Initially, it was found to produce doxorubicin which is widely used. In the year 1996, Strohl's group also discovered dox A. This is the gene that encodes the enzyme responsible for converting daunorubicin to DXR. By the year 1999, they produced a Cytochrome P450 oxidase, and found out that it catalyzes many steps in the biosynthesis or DXR, including steps leading to daunorubicin.
:
doxorubicininducedcardiomyopathy
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