Definition:
Eosinophilic granuloma is a rare disease often involving proliferation of clones of the langerhans cells, ana some abnormal cells from the bone marrow which are and capable of migrating from the skin to the lymph nodes. In a clinical test, its presentations may range from an isolated bone lesions to a disease involving many parts of the body systems.
Diagnosis:
Diagnosis of Eosinophilic granuloma may include the use of various tests like radiographs, bone scans, CT scans, or MRI.
Treatment:
Often times, lesions in the bones resolve slowly so it does not require any treatment not if they cause some symptoms. Curettage can provide a diagnostic biopsy material and is curative. When dealing with large or bigger lesions, they may need bone grafts. Injection of steroids in high dosages is also an option, this also tends to result in a faster curing of the lesion. A typical prescribed steroid dose is at 125 mg of methylprednisolone. Chemotherapy or the use of radiation therapy is not often indicated. Although steroids may not be as effective with multiple lesions. When used with chemotherapy, physicians often prescribe prednisolone and vinblastine. XRT treatment is only used when a symptpomatic lesion is locared in an inaccessible region like the pelvus, spine, or skull. Dose usually given is between 500 to 1000 rads.
Symptoms and Signs:
Eosinophilic granuloma is often associated with abnormal lesions in the muscles or bone areas.
Causes:
This condition often manifests as a result of some defects in metabolism especially in the reticuloendothelia system.
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