Definition:
Factor II deficiency is categorized is an extremely rare disorder. To date, there are only about 26 reported cases of this medical condition and is said to only occur 1 in 2 million individuals. This is known as an autosomal recessive disorder that equally affects both women and men. This is also known as prothrombin deficiency, which is identified as a precursor to thrombin and manifests as an abnormality of the prothrombin structure.
Diagnosis:
Diagnosis for Factor II deficiency is typically made through a prothrombin time (PT) test as well as the activated partial thromboplastin time (aPTT) test .
Treatment:
For patients who experience moderate bleeding can be treated with fresh frozen plasma, which can correct the prothrombin. Another treatment approach includes the use of Prothrombin complex concentrates (PCCs).
Symptoms and Signs:
Among the known symptoms associated with factor II deficiency include nosebleeds, abnormal bledding during and after delivery, abnormal menstrual bleeding, bruising, bleeding after trauma and surgery and umbilical cord bleeding among neonates.
Causes:
Among the leading causes of factor II deficiency includes vitamin K deficiency, liver diseases, bile duct obstructions as well as long-term use of antiobiotics and use of anticoagulant drugs that are known to prevent natural clotting of the blood.
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