Definition:
Antithrombin III (AT-III) deficiency is the shortage of the antithrombin III protein that is produced by the liver. Lack of sufficient antithrombin causes severe damages since the protein helps in making the blood coagulate.
Diagnosis:
The disease is diagnosed via genetic testing as well as blood serum tests.
Treatment:
Treatment of the disease is by preventing thrombosis to take place. Anticoagulating drugs may be given to patients who experience thromboembolic problems. Replacement therapy is now available to treat AT-III deficiency, but this is only done on delicate cases.
Symptoms and Signs:
Among the signs of AT-III deficiency are thromboembolic disorders which begin during puberty. Blood clots form in the legs, and lungs, which are presented by pain and incessant coughing.
Causes:
AT-III deficiency is an inherited disorder. It can also be an effect of maladies during pregnancy and use of oral contraceptives.
